Simmons was hurt while trying to beat out an infield hit in the eighth inning of Monday night’s loss to the Twins.
X-rays were negative, but the MRI confirmed the Grade 3 sprain. Simmons will see a foot and ankle specialist Wednesday, the team said.
Also, Shohei Ohtani will play Tuesday night against the Twins after taking a ball off his right finger while swinging at a third strike on Monday against Minnesota.
Ohtani will DH and bat third for the Angels.